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Biophysical differences in IgG1 Fc-based therapeutics relate to their cellular handling, interaction with FcRn and plasma half-life

In rodent models, Sema has been shown to activate GLP-1 receptors in the hypothalamus, indirectly affecting TSH (thyroid-stimulating hormone) levels and downstream thyroid hormone regulation

N., Cardoso, E

Pharmaceutical versions amplify these effects, reducing appetite and promoting satiety, or a feeling of fullness

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For some, this may feel like simple bloating, while others might notice pain, gassiness, or a stretched-out feeling in the abdomen